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Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy

The Consortium for Quality Assessment and Reproducibility for Instruments and Images in Light Microscopy (QUAREP-LiMi), formed by the global community of practitioners, researchers, developers, service providers, funders, publishers, policy makers and industry related to the use of light microscopy, is committed to democratising access to quantitative and reproducible light microscopy and the data generated by it.

Our mission is to provide a comprehensive set of community-agreed guidelines, protocols, automation procedures and other resources to improve quality control, quality assurance, and instrument/method calibration. The stakeholders advocate for the use of the highest level of reproducibility for data generated by light microscopy methods in scientific research and biotechnology applications. To support the achievement of its mission, QUAREP-LiMi:

 

  1. sanctions Working Groups to form teams that focus on specific technical or outreach topics,
  2. maintains, disseminates, and teaches best practices, protocols, and software tools and
  3. collaborates with providers of reference materials or instrumentation or other tools that facilitate the implementation of best practices at the community level.

 

QUAREP-LiMi operates a NextCloud and an OMERO server, which serve as a central repository and exchange point for our collective work. These platforms facilitate collaboration and data sharing between our members. 

QUAREP-LiMi is open to new members, and we look forward to your contribution. If you are interested in joining our initiative, please fill out our membership form. If you would like to change your Working Group (WG) or join a new WG, please use our form. For any further questions, please contact us.

Breaking News

A Community Effort: Bare Minimum Standards for Microscopy Methods Reporting or Establishing Community-Driven Minimal Guidelines for Microscopy Methods Reporting

WG11, as part of its mission to enhance publication standards for reproducible image-based science and in response to an inquiry from Nature Methods, has defined the "Bare Minimum Requirements for Microscopy Methods Reporting". This checklist, built upon the REMBI framework and the NBO-Q metadata model, is designed to guide researchers, scientific journals, and editors in the peer-review process, ensuring that microscopy methods across most applications include sufficient details for reproducibility.

Helena Jambor and Christopher Schmied honored at the annual award ceremony of the Einstein Foundation

©Copyright Einstein Foundation, Sebastian Gabsch

On Friday, 14.03.2025, Helena Jambor and Christopher Schmied of Quarep-LiMi WG12 were honored at the annual award ceremony of the Einstein Foundation Berlin, held at the Museum Bode in Berlin. They received the Einstein Foundation Early Career Award for promoting research quality with their project: “PixelQuality - Best practices for publishing images.”

The Early Career Award comes with a prize of EUR 100,000. Other award recipients included the platform PubPeer for the Institutional Award and Elisabeth Bik for the Individual Award.

In his keynote speech the former Minister of Education, Culture, and Science of the Netherlands, Robbert Dijkgraaf reflected on Einstein's career and the importance of freedom of science. In their greetings, Governing Mayor of Berlin Kai Wegner and Senator of Research, Health, and Care Ina Czyborra highlighted the significance of research for Berlin.

QUAREP-LiMi By-Laws have been published on Zenodo

In 2024, QUAREP-LiMi took a significant step forward by developing its By-Laws. Version 1.0 of the QUAREP-LiMi By-Laws has now been published on Zenodo. You can view and download them here::
https://zenodo.org/records/14884071

2024 Einstein Foundation Award Winners Colloquium

On March 13, 2025, Einstein Foundation Early Career Award winners Helena Jambor and Christopher Schmied, along with Elisabeth Bik and Brandon Stell, will host a colloquium titled "From Detection to Prevention: Improving the Scientific Publication Record Through Error Detection, Post-Publication Peer Review, and Image Guidelines."
The event will be available both online and in person. For more information and to register, visit: https://www.einsteinfoundation.de/en/insights/events/award/2024-einstein-foundation-award-winners-colloquium

Illumination Stability and Linearity Measurement Protocol V.3

WG 1 - Illumination Power published its third version of the protocol "Illumination Power, Stability and Linearity Measurements for Confocal, Widefield and Multiphoton Microscopes". The protocol is featured on protocols.io

Characterization of the Photon Conversion Factor, Noise, and Dynamic Range of Light Microscope Detection Systems

The WG 2 released its first protocol “Characterization of the Photon Conversion Factor, Noise, and Dynamic Range of Light Microscope Detection Systems“. In total there are 5 protocols belonging to the protocol:

  1. Introduction – Background and Aims
  2. Sample Preparation – An Easy-to-Prepare Sample Slide
  3. Data Generation – Systems with an Area Detector
  4. Data Generation – Systems with a Point Detector
  5. Analysis – Characterization of the Photon Conversion Factor, Noise, and Dynamic Range

The protocols are featured on

WG12 won the Einstein Early Career Award

The Einstein Early Career Award for Promoting Quality in Research celebrates outstanding early career researchers who are pioneering improvements in the quality, transparency, and reproducibility of science. Among this year’s inspiring finalists were Helene Jambor and Christopher Schmied, who took home the Award for their innovative work on guidelines to elevate the publication and analysis of scientific images. Their efforts are setting new standards in research and empowering scientists to create clearer, more reliable discoveries!

WG 12 nominated for the Einstein Early Career Award

Helena Jambor and Christopher Schmied from Working Group 12 have been selected as one of the five finalists for the 2024 Early Career Einstein Foundation Award with their proposal, "PixelQuality: Best Practices for Publishing Images". Their project will be presented at Berlin Science Week on November 5th. (For more information, visit Berlin Science Week.)
More information and registration for the online talk here: https://www.einsteinfoundation.de/en/insights/events/other/meet-the-finalists-early-career-award-2024 .

Article about QUAREP published in Imaging & Microscopy

In the latest edition of Imaging & Microscopy, readers will find a significant publication that sheds light on QUAREP-LiMi, titled "A Global Reproducibility Initiative in Light Microscopy." For those interested in a more in-depth exploration, the author's version of the article is readily available for download.

Annual Meeting Registration is now open

The upcoming Annual General Meeting is swiftly approaching and is scheduled for April 16, 2024. This year, we are offering the convenience of online participation. Registration for the meeting is currently open. To ensure your participation, please register in advance at the following link:

https://www.eventbrite.com/e/quarep-limi-annual-meeting-tickets-847086447367?aff=oddtdtcreator

The agenda can be downloaded here.

That is the direct zoom link for today, if you missed to register:

https://umassmed.zoom.us/j/99166849060?pwd=NTVvN0Y4bElwdEN3UHJJbU54cDRGdz09

Password: 031401

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Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy

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